IDENTIFICATION OF MARK2, CCDC71, GATA2, AND KLRC3 AS CANDIDATE DIAGNOSTIC GENES AND POTENTIAL THERAPEUTIC TARGETS FOR REPEATED IMPLANTATION FAILURE WITH ANTIPHOSPHOLIPID SYNDROME BY INTEGRATED BIOINFORMATICS ANALYSIS AND MACHINE LEARNING

BackgroundAntiphospholipid syndrome (APS) is a group of clinical syndromes of thrombosis or adverse pregnancy outcomes caused by antiphospholipid antibodies, which increase the incidence of Waterers in vitro fertilization failure in patients with infertility.However, the common mechanism of repeated implantation failure (RIF) with APS is unclear.Th

An extensive study of Neuropteroidea and Mecoptera collected in Grains Krasnodar Region and the Republic of Adygea in 2018 allowed the discovery of new species for the regions and for Russia, clarification of the taxonomic affiliation of some dubious specimens, and establish wellfounded conclusions about the ecological preferences of species.Nine s

Several studies have been conducted to reduce the idling noise of circular saws because the sound level is extremely high and harms the environment.However, conventional noise suppression technology only controls the vibrations of the circular saw itself, whereas idling noise can be generated when the air inside the enclosure is resonant.In this st

Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter.This silencing mechanism is seen in patient-derived lymphoblastoid cells but it remains unknown if it is a widespread phenomenon affecting multiple cell types and tissues.The humanized mouse mod